Depressant  

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Train wreck at Montparnasse (October 22, 1895) by Studio Lévy and Sons.
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Train wreck at Montparnasse (October 22, 1895) by Studio Lévy and Sons.

Depressants are psychoactive drugs which temporarily diminish the function or activity of a specific part of the body or mind. Examples of these kinds of effects may include anxiolysis, sedation, and hypotension. Due to their effects typically having a "down" quality to them, depressants are also occasionally referred to as "downers". Stimulants or "uppers", which increase mental and/or physical function, are in stark contrast to depressants and are considered to be their functional opposites. Depressants are widely used throughout the world as prescription medicines and as illicit substances. When these are used, effects may include anxiolysis, analgesia, sedation, somnolence, cognitive/memory impairment, dissociation, muscle relaxation, lowered blood pressure/heart rate, respiratory depression, anesthesia, and anticonvulsant effects. Some are also capable of inducing feelings of euphoria. Depressants exert their effects through a number of different pharmacological mechanisms, the most prominent of which include facilitation of GABA and/or opioid activity, and inhibition of adrenergic, histamine and/or acetylcholine activity.

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Unless indicated otherwise, the text in this article is either based on Wikipedia article "Depressant" or another language Wikipedia page thereof used under the terms of the GNU Free Documentation License; or on original research by Jahsonic and friends. See Art and Popular Culture's copyright notice.

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