Plague of Cyprian
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The Plague of Cyprian is the name given to a pandemic that afflicted the Roman Empire from about AD 249 to 262.
According to historian Kyle Harper, the period of the plague nearly saw the end of the Roman Empire. He states that between AD 248 and 268, ".. the history of Roman is a confusing tangle of violent failures. The structural integrity of the imperial machine burst apart. The frontier system crumbled. The collapse of legitimacy invited one usurper after another to try for the throne. The empire fragmented and only the dramatic success of later emperors in putting the pieces back together prevented this moment from being the final act of Roman imperial history."
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